Supervised Drug-Injection sites are being established now, one such site is in New York City. Here people can bring their intoxicating drugs, get them tested and injected under the supervision of trained staff, who if needed can administer a counter drug to control overdose.
Marijuana Business: Economic Effects of Interplay between the US Administrative Agencies to Regulate the Marijuana Industry
The US government is not backing off nor are the marijuana-related businesses (MRBs). Despite the prohibitions enumerated under the Controlled Substance Act of 1970 (CSA), the number of MRBs grew by 30% to 157,590 by June 2021 from 118,767 in September 2020.
Any proceeds from the business of the green plant may not be accepted by banks, therefore millions of dollars are stored under private vigilance. Any payment to and from the parties requires secured transportation without which the cash may fall prey to burglars.